Investigating brain changes linked to early Alzheimer's disease
Linking basal forebrain and entorhinal cortex vulnerability to preclinical Alzheimer's disease
This study is looking at how the brain changes in the early stages of Alzheimer's disease, focusing on two specific areas, to help find signs of the disease before symptoms show up, so we can catch it earlier and improve treatment options for people at risk.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project ID | NIH-10879127 on NIH RePORTER |
What this research studies
This research focuses on understanding how early changes in the brain related to Alzheimer's disease (AD) occur, particularly in two regions: the basal forebrain and the entorhinal cortex. By examining these areas side-by-side, the study aims to identify patterns of tau accumulation and brain atrophy that may signal the onset of AD before symptoms appear. Patients will undergo neuroimaging to assess these changes, which could lead to earlier detection and intervention strategies. The goal is to enhance our understanding of preclinical AD and its progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are cognitively healthy older adults who may be at risk for developing Alzheimer's disease.
Not a fit: Patients with advanced Alzheimer's disease or significant cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection of Alzheimer's disease, allowing for timely interventions that may slow cognitive decline.
How similar studies have performed: Previous research has shown promising results in understanding tau accumulation in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Berkeley, United States
- University of California Berkeley — Berkeley, United States (Active)
Researchers
- Principal investigator: Harrison, Theresa M. — University of California Berkeley
- Study coordinator: Harrison, Theresa M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.