Investigating brain changes in spinal muscular atrophy
The neuropathology of cerebellum in spinal muscular atrophy
['FUNDING_R15'] · DELAWARE STATE UNIVERSITY · NIH-10436518
This study is looking at how spinal muscular atrophy (SMA) affects a part of the brain called the cerebellum, which helps with movement, using special imaging techniques and mouse models to find out more about the brain changes in SMA, with the hope of improving treatments for people with this condition.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DELAWARE STATE UNIVERSITY (nih funded) |
| Locations | 1 site (DOVER, UNITED STATES) |
| Trial ID | NIH-10436518 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how spinal muscular atrophy (SMA) affects the cerebellum, an important part of the brain that coordinates movement. Using advanced imaging techniques like magnetic resonance imaging (MRI) and electrophysiological methods, the study aims to explore the neural circuits involved in SMA. By examining mouse models of the disease, researchers hope to uncover the underlying mechanisms of brain dysfunction associated with SMA, which could lead to better treatment strategies and prognoses for patients. The findings may provide insights into how SMA impacts not just motor neurons but also other areas of the nervous system.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with spinal muscular atrophy, particularly those who may benefit from insights into the disease's effects on the brain.
Not a fit: Patients with forms of muscular atrophy not related to spinal muscular atrophy may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of spinal muscular atrophy, potentially enhancing the quality of life for affected patients.
How similar studies have performed: While there has been significant research on spinal muscular atrophy, the specific focus on cerebellar pathology and neural circuits in this context is relatively novel.
Where this research is happening
DOVER, UNITED STATES
- DELAWARE STATE UNIVERSITY — DOVER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUN, JIANLI — DELAWARE STATE UNIVERSITY
- Study coordinator: SUN, JIANLI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.