Investigating brain changes in people living with HIV on treatment
PET IMAGING OF SYNAPTIC DENSITY COMBINED WITH NEUROIMMUNOLOGIC MEASURES TO REVEAL MECHANISMS OF HIV NEUROPATHOGENESIS DURING ART
['FUNDING_R01'] · YALE UNIVERSITY · NIH-10915683
This study is looking at how HIV affects brain health and thinking skills in people who are on treatment, using a special imaging technique to see changes in the brain over two years.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10915683 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the persistent neurological and cognitive impairments experienced by people living with HIV who are receiving antiretroviral therapy (ART). Using a novel PET imaging technique, the study aims to measure synaptic density in the brain over a period of 24 months. By tracking changes in synaptic density, researchers hope to uncover the underlying mechanisms of cognitive decline associated with HIV. This approach combines advanced imaging with neuroimmunologic measures to provide a comprehensive view of brain health in this population.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are currently on antiretroviral therapy and experiencing cognitive difficulties.
Not a fit: Patients who are not living with HIV or those who do not have cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for cognitive impairments in people living with HIV.
How similar studies have performed: Previous research has shown promise in using PET imaging to study brain function, suggesting that this approach could yield valuable insights into HIV-related cognitive issues.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SPUDICH, SERENA S — YALE UNIVERSITY
- Study coordinator: SPUDICH, SERENA S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus