Investigating brain changes in mice with HIV and opioid use
Single cell brain transcriptome changes during chronic HIV infection and opiate use in conventional mice
This study is looking at how chronic HIV and opioid use affect brain cells in mice to help us understand how these conditions might impact thinking and behavior in people living with HIV.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11021009 on NIH RePORTER |
What this research studies
This research explores how chronic HIV infection and opioid use affect brain cells in mice. By using advanced techniques like single cell sequencing, the study aims to understand the interactions between HIV and opioids at a cellular level. The researchers will focus on specific brain regions that influence cognition and behavior, which are impacted by both HIV and opioid addiction. This work could provide insights into the underlying mechanisms of addiction in individuals living with HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who also have a history of opioid use or addiction.
Not a fit: Patients who do not have HIV or a history of opioid use may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for individuals with HIV who also struggle with opioid addiction.
How similar studies have performed: Other research has shown promising results in understanding the interactions between HIV and addiction, making this approach both relevant and potentially impactful.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Kenny, Paul J. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Kenny, Paul J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.