Investigating brain changes in dementia with Lewy bodies and Alzheimer's disease
Official title: Neurodegeneration and Neuronal Fluctuations in DLB and AD
Funded at Mayo Clinic Arizona · NIH-11092092 · Data updated 2026-11-12
This study is looking at how the brains of people with dementia with Lewy bodies and Alzheimer's disease change over time, using special imaging tools to help doctors find better ways to diagnose and treat these conditions early on.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project start | July 5, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $156,535 |
| NIH project number | 5K23AG073525-05 |
| Project ID | NIH-11092092 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with dementia with Lewy bodies or Alzheimer's disease, particularly those experiencing early symptoms.
✕Less likely to help
Patients with other forms of dementia or cognitive impairment unrelated to Lewy bodies or Alzheimer's disease may not benefit from this research.
What this research studies
This research focuses on understanding the brain changes and underlying mechanisms in dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). It utilizes advanced imaging techniques like diffusion-weighted MRI and task-based electroencephalography to identify structural and functional alterations in the brain. By characterizing these changes, the study aims to improve the accuracy of early diagnosis and treatment strategies for patients with DLB and AD. This research addresses a critical need for better diagnostic tools and insights into the pathophysiology of these conditions.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnoses of dementia with Lewy bodies and Alzheimer's disease, improving treatment options and patient outcomes.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques to improve the understanding and diagnosis of neurodegenerative diseases, indicating that this approach may yield valuable insights.
Where this research is happening
-
Mayo Clinic Arizona
Scottsdale, United States Active
Researchers
- Principal investigator: Chiu, Shannon — Mayo Clinic Arizona
- Study coordinator: Chiu, Shannon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.