Investigating brain changes in dementia and Parkinson's disease
Neuropathology and Biochemistry Core
['FUNDING_OTHER'] · MAYO CLINIC JACKSONVILLE · NIH-10686895
This study is looking at brain samples from people who had dementia with Lewy bodies or Parkinson's disease to learn more about the changes in the brain that happen with these conditions, which could help improve how we diagnose and treat them in the future.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC JACKSONVILLE (nih funded) |
| Locations | 1 site (JACKSONVILLE, UNITED STATES) |
| Trial ID | NIH-10686895 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the brain pathology associated with dementia with Lewy bodies and Parkinsonian disease dementia. It involves the collection and analysis of postmortem brain samples to evaluate the presence of specific proteins and brain structures related to these conditions. By performing detailed neuropathologic evaluations, the research aims to provide valuable data that can help in the development of better diagnostic and therapeutic strategies for these dementias. Patients' brain samples will be analyzed for various markers, contributing to a deeper understanding of these diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with dementia with Lewy bodies or Parkinsonian disease dementia, particularly those who may be willing to donate their brain tissue postmortem.
Not a fit: Patients with other forms of dementia or neurological disorders unrelated to Lewy body pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods and treatments for patients suffering from Lewy body dementias.
How similar studies have performed: Previous research has shown success in using postmortem brain evaluations to understand neurodegenerative diseases, indicating that this approach is well-established.
Where this research is happening
JACKSONVILLE, UNITED STATES
- MAYO CLINIC JACKSONVILLE — JACKSONVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DICKSON, DENNIS WILLIAM — MAYO CLINIC JACKSONVILLE
- Study coordinator: DICKSON, DENNIS WILLIAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.