Investigating brain changes in Alzheimer's disease using advanced imaging techniques
Official title: Multi-scale MRI-based Diffeomorphometry of Pathology and Molecular Signatures Associated with Entorhinal Cortex Atrophy in Alzheimer's Disease
Funded at Johns Hopkins University · NIH-11183413 · Data updated 2026-11-12
This study is looking at how Alzheimer's disease affects certain parts of the brain, especially early changes in the entorhinal cortex, to help us understand which brain cells are most at risk and improve treatment options for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 30, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $866,723 |
| NIH project number | 1R56AG083478-01A1 |
| Project ID | NIH-11183413 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with early-stage Alzheimer's disease or those at high risk for developing the condition.
✕Less likely to help
Patients with advanced Alzheimer's disease or other forms of dementia unrelated to Alzheimer's may not benefit from this research.
What this research studies
This research focuses on understanding how Alzheimer's disease (AD) affects specific areas of the brain, particularly the entorhinal cortex, which shows early signs of pathology. By using advanced MRI imaging and analyzing brain tissue samples, the study aims to uncover the relationship between brain structure changes and molecular markers associated with AD. This approach will help identify how certain brain cells are more vulnerable to the disease, potentially leading to better treatment strategies. Patients may benefit from insights gained about the timing and nature of AD pathology.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and more effective treatments for Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques to study Alzheimer's pathology, indicating that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Miller, Michael I — Johns Hopkins University
- Study coordinator: Miller, Michael I
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.