Investigating brain changes in Alzheimer's disease through postmortem assessments.
Core D: Neuropathology Core
This study is looking at brain tissue from people who had Alzheimer's and related dementias after they have passed away, to help us learn more about these diseases and improve treatments, while also training new doctors and scientists in this important area.
Quick facts
| Grant type | P30 center grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11114236 on NIH RePORTER |
What this research studies
This research focuses on understanding the neuropathology of Alzheimer's disease and related dementias by conducting detailed postmortem assessments of brain tissue from participants. The Neuropathology Core at Johns Hopkins will perform autopsies on individuals who have been clinically characterized, allowing researchers to study the brain changes associated with these conditions. Additionally, the core will provide training for young physicians and scientists in the field of neuropathology, ensuring the next generation is equipped to tackle these diseases. The data collected will be integrated with clinical and biomarker information to enhance understanding and treatment of Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for participation are individuals diagnosed with Alzheimer's disease or related dementias who are enrolled in the Johns Hopkins Alzheimer’s Disease Research Center.
Not a fit: Patients who are not diagnosed with Alzheimer's disease or related dementias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for Alzheimer's disease and related dementias.
How similar studies have performed: Previous research has shown success in utilizing postmortem brain assessments to advance understanding of Alzheimer's disease pathology.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Troncoso, Juan — Johns Hopkins University
- Study coordinator: Troncoso, Juan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.