Investigating brain changes in Alzheimer's disease and related conditions
Official title: Ex Vivo Imaging of the Aging Brain to Discover Morphology/Pathology Associations
Funded at University of Pennsylvania · NIH-10608603 · Data updated 2026-11-12
This study is looking at how different brain changes related to Alzheimer's disease work together and affect brain health, using advanced imaging techniques on brain samples from people with the condition, to help us better understand how Alzheimer's progresses and how treatments might work.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | April 15, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $2,077,693 |
| NIH project number | 2RF1AG056014-06 |
| Project ID | NIH-10608603 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias who are undergoing autopsy.
✕Less likely to help
Patients with early-stage Alzheimer's disease who are not yet diagnosed or those with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
What this research studies
This research focuses on understanding the complex changes in the brain associated with Alzheimer's disease (AD) by examining both the primary and co-existing pathologies that contribute to neurodegeneration. Using advanced ex vivo MRI techniques, the study will analyze brain samples from individuals diagnosed with AD to identify how these different pathologies interact and affect brain health. The research aims to provide insights into the varying contributions of these pathologies to neuronal loss and cortical thinning, which could improve the understanding of AD progression and treatment responses.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment strategies for Alzheimer's disease by identifying multiple pathological contributors to the disease.
How similar studies have gone: Previous research has shown that understanding the heterogeneity of Alzheimer's disease pathologies can lead to improved treatment approaches, indicating that this study builds on established findings.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Yushkevich, Paul a. — University of Pennsylvania
- Study coordinator: Yushkevich, Paul a.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.