Investigating brain changes in a mouse model of Alzheimer's disease
Multimodal imaging of prodromal synaptic, circuit, and network-level dysfunction in a murine model of Alzheimer's disease
This study is looking at how Alzheimer's disease changes the way the brain is organized and connected, using special imaging techniques on mice that have been modified to show Alzheimer's traits, with the hope that the results will help in creating early treatments and prevention strategies for people with the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10562876 on NIH RePORTER |
What this research studies
This research explores how Alzheimer's disease affects brain organization at various levels, from individual synapses to overall brain connectivity. By using a combination of advanced imaging techniques, the study aims to uncover the mechanisms behind these changes and how they relate to the onset of symptoms. The research will utilize a mouse model genetically modified to exhibit Alzheimer's characteristics, allowing for detailed observation of brain function and behavior. The findings could inform the development of early treatments and preventative strategies for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be individuals at risk for Alzheimer's disease or those in the early stages of cognitive decline.
Not a fit: Patients with advanced Alzheimer's disease or those not exhibiting early symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and strategies for early intervention in Alzheimer's disease.
How similar studies have performed: Other research has shown promise using multimodal imaging approaches to study Alzheimer's disease, indicating potential for success in this area.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Toyonaga, Takuya — Yale University
- Study coordinator: Toyonaga, Takuya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.