Investigating brain changes and cognitive factors in people with schizotypal personality disorder.
Longitudinal neuroimaging and neurocognitive assessment of risk and protective factors across the schizophrenia spectrum
This study is looking at how schizotypal personality disorder affects the brain and thinking skills over time, and it's for people with this condition who want to help researchers learn more about it and find ways to prevent more serious symptoms.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10754910 on NIH RePORTER |
What this research studies
This research focuses on understanding schizotypal personality disorder (SPD), which shares similarities with schizophrenia but has milder symptoms. By using advanced neuroimaging techniques and cognitive assessments, the study aims to identify brain abnormalities and protective factors that may prevent the development of more severe psychotic symptoms. Participants will undergo longitudinal evaluations, allowing researchers to track changes over time and better understand the relationship between brain function and cognitive abilities in individuals with SPD. This approach is unique as it avoids confounding factors present in schizophrenia, such as medication effects.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with schizotypal personality disorder.
Not a fit: Patients with full-blown schizophrenia or those without any psychotic spectrum disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for individuals at risk of developing schizophrenia.
How similar studies have performed: While there has been research on schizophrenia, this longitudinal approach specifically targeting schizotypal personality disorder is novel and has not been extensively studied.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Hazlett, Erin a. — Icahn School of Medicine at Mount Sinai
- Study coordinator: Hazlett, Erin a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.