Investigating brain changes and blood markers in patients with lingering symptoms after Lyme disease treatment
Neuroimaging and blood markers in post treatment Lyme disease with persistent neurologic symptoms
This study is looking at how Lyme disease treatment affects brain activity and symptoms in patients, by comparing them to healthy people over a year, to help understand why some still feel unwell afterward.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10932440 on NIH RePORTER |
What this research studies
This research focuses on understanding the neurological symptoms that some patients experience after being treated for Lyme disease. It will involve tracking changes in brain activity and white matter using functional MRI over a period of 12 months in patients who have had early Lyme disease. The study will compare these patients to healthy individuals to identify potential mechanisms behind persistent symptoms. By analyzing blood markers alongside neuroimaging data, the research aims to uncover insights into the healing process and cognitive performance in these patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with early Lyme disease and are experiencing persistent neurological symptoms after antibiotic treatment.
Not a fit: Patients who have not been treated for Lyme disease or those without neurological symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from post-treatment Lyme disease.
How similar studies have performed: Previous research has indicated that neuroimaging and biomarker analysis can provide valuable insights into neurological conditions, suggesting potential for success in this approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Marvel, Cherie L — Johns Hopkins University
- Study coordinator: Marvel, Cherie L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.