Investigating brain changes and biomarkers after concussion related to Alzheimer's disease.
Neuroimaging and Molecular Markers of AD and Neurodegenerative Disease after Concussion
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-10563143
This study is looking at how mild brain injuries, like concussions, might raise the chances of developing Alzheimer's and other brain conditions, and it’s for anyone who has had a concussion and wants to help us learn more about brain health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-10563143 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how mild traumatic brain injury (TBI), such as concussions, may increase the risk of developing Alzheimer's disease and other neurodegenerative conditions. By examining genetic, epigenetic, and blood-based protein biomarkers alongside MRI brain scans, the study aims to identify early indicators of neurodegeneration that could arise after a concussion. The goal is to uncover the mechanisms linking mild TBI to Alzheimer's, which could help in early diagnosis and intervention. Patients may be monitored over time to assess changes in their brain health and identify risk factors.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have suffered a mild TBI or concussion, particularly those with additional risk factors for Alzheimer's disease.
Not a fit: Patients who have not experienced a concussion or do not have risk factors for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to early detection and preventive strategies for Alzheimer's disease in individuals who have experienced concussions.
How similar studies have performed: Other research has indicated potential links between mild TBI and neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HAYES, JASMEET PANNU — OHIO STATE UNIVERSITY
- Study coordinator: HAYES, JASMEET PANNU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease