Investigating brain changes after radiation therapy using PET imaging
PET Biomarker for synaptic density changes after radiation therapy
['FUNDING_R01'] · CHILDREN'S HOSP OF PHILADELPHIA · NIH-10850238
This study is looking at how radiation therapy for brain tumors might change the connections in the brain that help us think, using a special imaging technique to see these changes in both kids and adults, with the hope of finding ways to help improve thinking skills after treatment.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S HOSP OF PHILADELPHIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10850238 on ClinicalTrials.gov |
What this research studies
This research aims to explore how radiation therapy affects synaptic density in the brain, which is crucial for cognitive function. Using a specialized imaging technique called positron emission tomography (PET), the study will track changes in synaptic density in both children and adults who have undergone targeted radiation therapy for brain tumors. By correlating these changes with cognitive outcomes, the research seeks to uncover the mechanisms behind cognitive decline post-treatment. The ultimate goal is to identify potential therapeutic strategies to mitigate these cognitive impairments.
Who could benefit from this research
Good fit: Ideal candidates for this research include both children and adults who are undergoing radiation therapy for central nervous system malignancies.
Not a fit: Patients who are not receiving radiation therapy or those with conditions unrelated to cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent cognitive decline in patients receiving radiation therapy for brain tumors.
How similar studies have performed: Previous research has shown promising results in using PET imaging to study brain changes, indicating that this approach may yield valuable insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- CHILDREN'S HOSP OF PHILADELPHIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ABOIAN, MARIAM — CHILDREN'S HOSP OF PHILADELPHIA
- Study coordinator: ABOIAN, MARIAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury