Investigating brain changes after moderate traumatic brain injury and potential treatment with MitoQ
Persistent Pre- and Post-Synaptic Changes After Moderate Traumatic Brain Injury and Mitigation with MitoQ
This study is looking at how moderate brain injuries, especially in military personnel, change the brain over time and how these changes impact recovery and daily life, while also testing a possible treatment called MitoQ to help improve healing and overall well-being.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Decatur, UNITED STATES) |
| Project ID | NIH-10914645 on NIH RePORTER |
What this research studies
This research focuses on understanding the long-term changes in the brain that occur after moderate traumatic brain injury (TBI), particularly in military personnel. It examines how these changes affect brain recovery and daily functioning, with a specific interest in the role of oxidative stress and synaptic alterations. The study will utilize animal models to explore the effects of a potential treatment, MitoQ, on these persistent brain changes. By identifying the mechanisms involved, the research aims to develop strategies to improve recovery and quality of life for individuals affected by TBI.
Who could benefit from this research
Good fit: Ideal candidates for this research are military personnel and veterans who have experienced moderate traumatic brain injuries.
Not a fit: Patients with mild or severe traumatic brain injuries may not benefit from this specific research focused on moderate TBI.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance brain recovery and daily functioning for individuals with traumatic brain injury.
How similar studies have performed: While there have been limited studies on chronic synaptic changes after TBI, this research explores novel aspects that have not been extensively tested.
Where this research is happening
Decatur, UNITED STATES
- Veterans Health Administration — Decatur, United States (Active)
Researchers
- Principal investigator: Wang, Kevin Ka Wang — Veterans Health Administration
- Study coordinator: Wang, Kevin Ka Wang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.