Investigating brain changes after moderate traumatic brain injury and potential treatment with MitoQ
Official title: Persistent Pre- and Post-Synaptic Changes After Moderate Traumatic Brain Injury and Mitigation with MitoQ
Funded at Veterans Health Administration · NIH-10914645 · Data updated 2026-11-12
This study is looking at how moderate brain injuries, especially in military personnel, change the brain over time and how these changes impact recovery and daily life, while also testing a possible treatment called MitoQ to help improve healing and overall well-being.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Decatur, UNITED STATES) |
| Project start | August 1, 2023 |
| Project end | September 30, 2028 |
| Funding year | 2024 |
| NIH project number | 5I01RX003832-02 |
| Project ID | NIH-10914645 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are military personnel and veterans who have experienced moderate traumatic brain injuries.
✕Less likely to help
Patients with mild or severe traumatic brain injuries may not benefit from this specific research focused on moderate TBI.
What this research studies
This research focuses on understanding the long-term changes in the brain that occur after moderate traumatic brain injury (TBI), particularly in military personnel. It examines how these changes affect brain recovery and daily functioning, with a specific interest in the role of oxidative stress and synaptic alterations. The study will utilize animal models to explore the effects of a potential treatment, MitoQ, on these persistent brain changes. By identifying the mechanisms involved, the research aims to develop strategies to improve recovery and quality of life for individuals affected by TBI.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance brain recovery and daily functioning for individuals with traumatic brain injury.
How similar studies have gone: While there have been limited studies on chronic synaptic changes after TBI, this research explores novel aspects that have not been extensively tested.
Where this research is happening
-
Veterans Health Administration
Decatur, United States Active
Researchers
- Principal investigator: Wang, Kevin Ka Wang — Veterans Health Administration
- Study coordinator: Wang, Kevin Ka Wang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.