Investigating brain cells as a hidden reservoir for HIV
Defining brain pericytes as a novel and myeloid-derived HIV reservoir
This study is looking at how specific brain cells can hold onto HIV and keep the virus active, which can cause ongoing health issues for people living with HIV, and it aims to find new ways to get rid of the virus from the brain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project ID | NIH-11078206 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain brain cells, specifically brain pericytes, can harbor HIV and contribute to ongoing viral replication in the brain. By examining the characteristics of these cells, the study aims to uncover how they may serve as a reservoir for the virus, leading to chronic inflammation and neurological complications in HIV-infected individuals. The research employs advanced techniques to analyze the infection process and the potential for these cells to reactivate the virus. Ultimately, the goal is to identify new strategies for eradicating HIV from the central nervous system.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who may be experiencing neurological symptoms or complications.
Not a fit: Patients who are not infected with HIV or those who do not have neurological complications related to HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that effectively eliminate HIV reservoirs in the brain, improving health outcomes for individuals living with HIV.
How similar studies have performed: While research on HIV reservoirs has been conducted, the specific focus on brain pericytes as a novel reservoir is relatively new and has not been extensively tested.
Where this research is happening
Coral Gables, United States
- University of Miami School of Medicine — Coral Gables, United States (Active)
Researchers
- Principal investigator: Toborek, Michal — University of Miami School of Medicine
- Study coordinator: Toborek, Michal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.