Investigating brain cell vulnerabilities in Alzheimer's disease
Single-cell transcriptomic and epigenomic analysis of brain cell vulnerabilities to tauopathies in early AD impacted brain regions
This study is looking at how Alzheimer's disease affects different types of brain cells in mice, hoping to find out which cells are most at risk and how our genes might play a role, with the goal of discovering new ways to treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11051809 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific brain cells are affected by Alzheimer's disease (AD) at a molecular level. By using advanced techniques like single-cell transcriptomics and epigenomics, the team will analyze brain cell changes in various mouse models that mimic human AD. The study aims to identify which cell types are most vulnerable to damage and how genetic factors influence these vulnerabilities. This could lead to a better understanding of the disease and potential new treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Alzheimer's disease, particularly those with genetic predispositions or early signs of cognitive decline.
Not a fit: Patients with advanced Alzheimer's disease or those with other unrelated neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that protect vulnerable brain cells in Alzheimer's patients.
How similar studies have performed: Previous research has shown promise in using similar approaches to understand neurodegenerative diseases, indicating potential for success in this novel investigation.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Xu, Xiangmin — University of California-Irvine
- Study coordinator: Xu, Xiangmin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.