Investigating brain cell vulnerabilities in Alzheimer's disease
Official title: Single-cell transcriptomic and epigenomic analysis of brain cell vulnerabilities to tauopathies in early AD impacted brain regions
Funded at University of California-Irvine · NIH-11051809 · Data updated 2026-11-12
This study is looking at how Alzheimer's disease affects different types of brain cells in mice, hoping to find out which cells are most at risk and how our genes might play a role, with the goal of discovering new ways to treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | June 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,979,459 |
| NIH project number | 5R01AG082127-03 |
| Project ID | NIH-11051809 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for Alzheimer's disease, particularly those with genetic predispositions or early signs of cognitive decline.
✕Less likely to help
Patients with advanced Alzheimer's disease or those with other unrelated neurological conditions may not benefit from this research.
What this research studies
This research focuses on understanding how specific brain cells are affected by Alzheimer's disease (AD) at a molecular level. By using advanced techniques like single-cell transcriptomics and epigenomics, the team will analyze brain cell changes in various mouse models that mimic human AD. The study aims to identify which cell types are most vulnerable to damage and how genetic factors influence these vulnerabilities. This could lead to a better understanding of the disease and potential new treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that protect vulnerable brain cells in Alzheimer's patients.
How similar studies have gone: Previous research has shown promise in using similar approaches to understand neurodegenerative diseases, indicating potential for success in this novel investigation.
Where this research is happening
-
University of California-Irvine
Irvine, United States Active
Researchers
- Principal investigator: Xu, Xiangmin — University of California-Irvine
- Study coordinator: Xu, Xiangmin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.