Investigating brain cell types involved in opioid addiction using advanced genetic techniques
Multiomic profiling of cell types mediating opioid use disorder in rats
This study is looking at how different brain cells change when exposed to opioids, using rats to help us understand addiction better, which could lead to new and better treatments for people struggling with opioid use.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11082311 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific brain cell types are affected by opioid exposure, particularly in the context of addiction. Using a rat model that mimics human opioid use disorders, the study employs cutting-edge multi-omics techniques to analyze both gene expression and epigenetic changes in brain cells. By mapping these cellular responses, the research aims to uncover the underlying mechanisms of opioid addiction, which could lead to improved treatment strategies. Patients may benefit from insights gained into the biological basis of addiction, potentially informing future therapies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be individuals with a history of opioid use disorder or those at risk of developing such disorders.
Not a fit: Patients who do not have a history of opioid use or are not affected by substance use disorders may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for individuals struggling with opioid addiction.
How similar studies have performed: Other research has shown promise using similar multi-omics approaches to study addiction, indicating potential for success in this novel application.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Telese, Francesca — University of California, San Diego
- Study coordinator: Telese, Francesca
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.