Investigating brain cell interactions and changes in early psychosis using patient-derived stem cells
Dysfunctional neurovascular interactions and neuroprogression in early-course psychosis: ex vivo investigation with patient-derived stem cells
This study is looking at how brain cells and the protective barrier around the brain work together and might affect the early symptoms of psychosis, using special cells from patients to create models that help us learn more about what's happening in the brain, which could lead to better treatments for you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11132270 on NIH RePORTER |
What this research studies
This research focuses on understanding how interactions between brain cells and the blood-brain barrier may contribute to the progression of symptoms in early-course psychosis. By using patient-derived stem cells, the study aims to create models that mimic the brain's environment to investigate cellular and molecular changes. The approach includes developing assays to measure the function of brain microvascular cells and neurons, which could reveal important insights into the mechanisms of neuroprogression. Patients may benefit from a better understanding of their condition and potential new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with early-course psychosis who are experiencing cognitive and functional decline.
Not a fit: Patients with psychotic disorders who are not in the early stages of their condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and interventions for individuals experiencing early psychosis.
How similar studies have performed: While some studies have explored aspects of neuroprogression and blood-brain barrier dysfunction, this research aims to establish novel mechanistic links that have not been previously tested.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Karmacharya, Rakesh — Massachusetts General Hospital
- Study coordinator: Karmacharya, Rakesh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.