Investigating brain cell growth and inflammation in schizophrenia
Neuroinflammation and Neurogenesis in Schizophrenia
['FUNDING_R01'] · UPSTATE MEDICAL UNIVERSITY · NIH-11058479
This study is looking at how the creation of new brain cells is changed in people with schizophrenia, and it hopes to find out how inflammation and certain immune cells might be affecting this process, which could help develop new ways to support brain health for those with the condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UPSTATE MEDICAL UNIVERSITY (nih funded) |
| Locations | 1 site (SYRACUSE, UNITED STATES) |
| Trial ID | NIH-11058479 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how the generation of new neurons from stem cells is affected in individuals with schizophrenia. By examining single cells, the study aims to identify changes in the transcriptional profiles of neurogenic cells and determine at which stage neurogenesis is disrupted. It will also explore the role of macrophages in the neurogenic niche and how inflammation influences these processes. The findings could lead to new strategies for restoring neurogenesis in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have been diagnosed with schizophrenia.
Not a fit: Patients with schizophrenia who are under 21 years old or those without a diagnosis of schizophrenia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance brain cell growth and improve outcomes for individuals with schizophrenia.
How similar studies have performed: Previous research has shown promising results in understanding neuroinflammation and neurogenesis in other neurological conditions, suggesting potential for success in this area as well.
Where this research is happening
SYRACUSE, UNITED STATES
- UPSTATE MEDICAL UNIVERSITY — SYRACUSE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WEICKERT, CYNTHIA SHANNON — UPSTATE MEDICAL UNIVERSITY
- Study coordinator: WEICKERT, CYNTHIA SHANNON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.