Investigating brain cell dysfunction in Fragile X Syndrome
Multilevel Analysis of Cortical Interneuron Dysfunction in Fragile X Syndrome
This study is looking at how specific brain cells work in people with Fragile X Syndrome, using a mouse model to help understand their role in the condition and related issues like autism, with the hope of finding new ways to help.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10746852 on NIH RePORTER |
What this research studies
This research focuses on understanding how certain brain cells, known as cortical interneurons, function in individuals with Fragile X Syndrome (FXS). By studying a mouse model of FXS, researchers aim to uncover the role of these interneurons in the condition's development and how they may contribute to related disorders like autism. The study employs innovative techniques to analyze the number, distribution, and connections of these cells, which are often overlooked in FXS research. The findings could provide insights into the underlying mechanisms of FXS and potentially lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Fragile X Syndrome or those exhibiting autism-like features associated with the condition.
Not a fit: Patients without a diagnosis of Fragile X Syndrome or related neurodevelopmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for individuals with Fragile X Syndrome and related neurodevelopmental disorders.
How similar studies have performed: While the specific focus on cortical interneurons in FXS is relatively novel, previous research has shown success in studying synaptic defects in related neurodevelopmental disorders.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Au, Edmund — Columbia University Health Sciences
- Study coordinator: Au, Edmund
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.