Investigating brain cell dysfunction in autism
Cerebellar granule cell dysfunction in Shank3 mutant mice
['FUNDING_R01'] · SOUTHERN ILLINOIS UNIVERSITY SCH OF MED · NIH-11080992
This study is looking at how certain brain cells in the cerebellum might not work properly in people with autism, using special mice to help understand the problem better, which could give us clues about how brain health affects behaviors related to autism.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SOUTHERN ILLINOIS UNIVERSITY SCH OF MED (nih funded) |
| Locations | 1 site (SPRINGFIELD, UNITED STATES) |
| Trial ID | NIH-11080992 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how specific brain cells in the cerebellum may be dysfunctional in individuals with autism spectrum disorder (ASD). By studying Shank3 mutant mice, which serve as a model for ASD, the research aims to identify the neural mechanisms that contribute to the disorder. The approach involves examining the cerebellar granule cells, which are crucial for processing sensory and motor information, to see how genetic mutations affect their function. This could lead to insights into the broader implications of cerebellar health on behaviors associated with autism.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autism spectrum disorder, particularly those with genetic mutations similar to Shank3.
Not a fit: Patients without autism spectrum disorder or those whose conditions do not involve cerebellar dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies targeting cerebellar dysfunction in individuals with autism.
How similar studies have performed: While there has been significant research on the genetic aspects of autism, the specific focus on cerebellar granule cells in relation to ASD is relatively novel and has not been extensively tested.
Where this research is happening
SPRINGFIELD, UNITED STATES
- SOUTHERN ILLINOIS UNIVERSITY SCH OF MED — SPRINGFIELD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RICHARDSON, BEN D — SOUTHERN ILLINOIS UNIVERSITY SCH OF MED
- Study coordinator: RICHARDSON, BEN D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.