Investigating brain cell changes in HIV-infected individuals with addiction
Single nuclei transcriptome profiling in addiction circuitry of the HIV+ brain
['FUNDING_U01'] · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · NIH-11056062
This study is looking at how HIV affects the brain, especially in people who also have issues with substance use, to better understand how these two challenges impact thinking and memory.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11056062 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how HIV affects brain function, particularly in individuals who also struggle with substance use disorders. By examining brain tissues from HIV-infected individuals, the study aims to uncover the relationship between HIV integration and neurocognitive disorders. The researchers will analyze specific brain regions that are impacted by both HIV and addiction, using advanced genomic techniques to explore how these factors interact at a cellular level. This work could provide insights into the mechanisms behind cognitive deficits in this population.
Who could benefit from this research
Good fit: Ideal candidates for this research are HIV-positive individuals who also have a history of substance use disorders.
Not a fit: Patients who are HIV-negative or do not have substance use disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for cognitive disorders in HIV-infected individuals, particularly those with substance use issues.
How similar studies have performed: Previous research has shown promising results in understanding the interplay between HIV and neurocognitive disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW YORK, UNITED STATES
- ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AKBARIAN, SCHAHRAM — ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Study coordinator: AKBARIAN, SCHAHRAM
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus, addictive disorder