Investigating brain blood vessel issues in people recovering from COVID-19
Magnetic Resonance Imaging Biomarkers of Post-COVID-19 Cerebral Microvascular Dysfunction
This study is looking at how COVID-19 might affect the brain in some people after they recover, especially focusing on issues with tiny blood vessels that could lead to problems like memory loss and mood swings, and it’s for anyone who has experienced these lingering symptoms after their COVID-19 illness.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11089438 on NIH RePORTER |
What this research studies
This research focuses on understanding the neurological effects that some individuals experience after recovering from COVID-19, known as neuro-PASC. It aims to identify specific brain blood vessel problems using advanced MRI techniques, which may contribute to symptoms like cognitive impairment and mood changes. By examining these microvascular issues, the study seeks to uncover the underlying causes of these persistent symptoms and assess the risk of developing further complications, such as vascular dementia. Participants will undergo MRI scans to help identify biomarkers associated with these brain changes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 who have experienced neurological symptoms after recovering from COVID-19.
Not a fit: Patients who have not had COVID-19 or do not exhibit neurological symptoms related to the virus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for cognitive and neurological issues following COVID-19.
How similar studies have performed: Other research has indicated that examining microvascular dysfunction can provide valuable insights into post-viral neurological conditions, suggesting a promising avenue for this investigation.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Mcalpine, Lindsay — Yale University
- Study coordinator: Mcalpine, Lindsay
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.