Investigating brain blood flow responses in older adults with cognitive impairment
Administrative supplement of gas-free cerebrovascular reactivity (CVR) MRI in vascular cognitive impairment
This study is looking at how blood flow in the brains of older adults with HIV reacts to different things, using a new MRI method to see how well their blood vessels work, which could help spot early signs of thinking and memory problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10844887 on NIH RePORTER |
What this research studies
This research focuses on understanding how blood flow in the brain responds to certain stimuli in older adults, particularly those living with HIV. It aims to develop a new MRI technique to measure cerebrovascular reactivity (CVR), which is how well blood vessels in the brain can expand and contract. By examining these responses, the research seeks to identify early signs of vascular cognitive impairment, a condition that affects thinking and memory. Participants may undergo MRI scans to assess their brain's vascular function and its relationship to cognitive health.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 50 and above who are living with HIV and may be experiencing cognitive challenges.
Not a fit: Patients who are younger than 50 or do not have HIV may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better management of cognitive impairments in older adults with HIV.
How similar studies have performed: Previous studies have shown promising results in measuring cerebrovascular reactivity in similar populations, indicating that this approach may be effective.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Liu, Peiying — University of Maryland Baltimore
- Study coordinator: Liu, Peiying
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.