Investigating brain and cognitive outcomes in Ugandan infants with hydrocephalus after treatment.
Neurocognitive outcomes and changes in brain and CSF volume after treatment of post-infectious hydrocephalus in Ugandan infants by shunting or ETV/CPC: a randomized prospective trial
This study is looking at how two different treatments for post-infectious hydrocephalus affect the brain development and learning abilities of babies under six months old, so we can better understand which option helps them grow and thrive as they get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10890005 on NIH RePORTER |
What this research studies
This research focuses on understanding how different treatments for post-infectious hydrocephalus affect brain development and cognitive outcomes in infants under six months old. The study compares two treatment methods: endoscopic third ventriculostomy with choroid plexus cauterization (ETV/CPC) and traditional shunt placement. By following these infants over several years, researchers aim to assess changes in brain and cerebrospinal fluid (CSF) volume and their correlation with developmental progress. This long-term follow-up will provide valuable insights into the effectiveness of these treatments as the children grow.
Who could benefit from this research
Good fit: Ideal candidates for this research are Ugandan infants under six months old diagnosed with post-infectious hydrocephalus.
Not a fit: Patients who are older than six months or have hydrocephalus due to non-infectious causes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for hydrocephalus, enhancing cognitive development and quality of life for affected infants.
How similar studies have performed: Previous studies have shown promising results with similar treatment approaches, indicating potential for significant advancements in managing hydrocephalus.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Schiff, Steven J — Yale University
- Study coordinator: Schiff, Steven J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.