Investigating brain and cognitive outcomes in Ugandan infants with hydrocephalus after treatment.
Official title: Neurocognitive outcomes and changes in brain and CSF volume after treatment of post-infectious hydrocephalus in Ugandan infants by shunting or ETV/CPC: a randomized prospective trial
Funded at Yale University · NIH-10890005 · Data updated 2026-11-12
This study is looking at how two different treatments for post-infectious hydrocephalus affect the brain development and learning abilities of babies under six months old, so we can better understand which option helps them grow and thrive as they get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | November 1, 2022 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $492,174 |
| NIH project number | 5R01HD085853-11 |
| Project ID | NIH-10890005 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are Ugandan infants under six months old diagnosed with post-infectious hydrocephalus.
✕Less likely to help
Patients who are older than six months or have hydrocephalus due to non-infectious causes may not benefit from this research.
What this research studies
This research focuses on understanding how different treatments for post-infectious hydrocephalus affect brain development and cognitive outcomes in infants under six months old. The study compares two treatment methods: endoscopic third ventriculostomy with choroid plexus cauterization (ETV/CPC) and traditional shunt placement. By following these infants over several years, researchers aim to assess changes in brain and cerebrospinal fluid (CSF) volume and their correlation with developmental progress. This long-term follow-up will provide valuable insights into the effectiveness of these treatments as the children grow.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for hydrocephalus, enhancing cognitive development and quality of life for affected infants.
How similar studies have gone: Previous studies have shown promising results with similar treatment approaches, indicating potential for significant advancements in managing hydrocephalus.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Schiff, Steven J — Yale University
- Study coordinator: Schiff, Steven J
Related research
Other NIH-funded projects on the same topics.
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Targeting the brain’s fluid system to treat post-hemorrhagic hydrocephalus
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Endoscopic versus Shunt Treatment of Hydrocephalus in Infants
A study compares two treatments for hydrocephalus in infants to see which keeps babies cognitively on par with the standard shunt treatment.
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Endoscopic treatment versus shunt for hydrocephalus in infants
This project tests whether a shunt-free endoscopic procedure can be as good as traditional shunting for babies with hydrocephalus.
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Endoscopic treatment vs shunt for infant hydrocephalus
Infants with hydrocephalus may be treated with a shunt or a shunt-free procedure called ETV+CPC, and this study compares the two to see if the shunt-free option can keep cognitive outcomes similar.
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Functional screen of hydrocephalus and heart-disease genes in a frog model
A study uses frog embryos to test how human genetic changes might cause congenital hydrocephalus and related heart defects, with the goal of understanding why these conditions occur.
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Modulating choroid plexus function to restore CSF balance in hydrocephalus
A new NIH grant aims to adjust the choroid plexus, the brain’s CSF factory, to restore normal CSF flow and reduce hydrocephalus-related problems.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.