Investigating brain and behavior in older adults with schizophrenia
Official title: A Schizophrenia Extension Study for the NKI Rockland Sample II project: An Open Resource of Multimodal Brain, Physiology & Behavior from a Community Lifespan Sample
Funded at Nathan S. Kline Institute for Psych Res · NIH-11138750 · Data updated 2026-11-12
This study is looking at how schizophrenia affects older adults by gathering information about their brain activity, physical health, and behaviors, to better understand things like aggression, suicidal thoughts, and loneliness, and the results will be shared to help improve care for others.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Nathan S. Kline Institute for Psych Res NIH-funded |
| Lab location | 1 site (Orangeburg, United States) |
| Project start | July 15, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $697,532 |
| NIH project number | 5R01MH137769-02 |
| Project ID | NIH-11138750 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 85 and older who have been diagnosed with schizophrenia.
✕Less likely to help
Patients without a diagnosis of schizophrenia or those younger than 85 years old may not receive any benefit from this research.
What this research studies
This research focuses on understanding schizophrenia in older adults by creating a comprehensive database that includes brain imaging, physiological data, and behavioral assessments. It utilizes advanced technologies like EEG and fMRI to explore the neural mechanisms associated with the disorder. By analyzing data from a large community sample, the study aims to identify risk factors for aggression and suicidality, as well as the impact of loneliness on health outcomes. The findings will be shared openly to facilitate further clinical investigations.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for older adults suffering from schizophrenia.
How similar studies have gone: Previous research has shown success in using multimodal approaches to study schizophrenia, indicating that this method could yield valuable insights.
Where this research is happening
-
Nathan S. Kline Institute for Psych Res
Orangeburg, United States Active
Researchers
- Principal investigator: Javitt, Daniel C. — Nathan S. Kline Institute for Psych Res
- Study coordinator: Javitt, Daniel C.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.