Investigating brain aging and Alzheimer's disease in a Korean cohort
KBASE2: Korean Brain Aging Study, Longitudinal Endophenotypes and Systems Biology
This study is looking at how our brains change as we age and how that relates to Alzheimer's disease, by gathering information from a diverse group of people in Korea, including those who are healthy and those with memory issues, to help find clues for early diagnosis and better understanding of the disease.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10877166 on NIH RePORTER |
What this research studies
This research focuses on understanding brain aging and Alzheimer's disease by analyzing a large cohort of participants from Korea, ranging from cognitively normal individuals to those with mild cognitive impairment and Alzheimer's dementia. The study collects extensive clinical, cognitive, and lifestyle data, along with advanced neuroimaging and genetic information. By collaborating with multiple institutions, the research aims to identify biomarkers and genetic factors that contribute to Alzheimer's disease progression and early diagnosis.
Who could benefit from this research
Good fit: Ideal candidates for participation include Korean individuals aged 20 to 90, particularly those with mild cognitive impairment or Alzheimer's disease.
Not a fit: Patients with advanced Alzheimer's disease or those outside the specified age range may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved early diagnosis and personalized treatment strategies for Alzheimer's disease.
How similar studies have performed: Previous studies, such as the North American Alzheimer’s Disease Neuroimaging Initiative, have shown success in similar approaches to understanding Alzheimer's disease.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Saykin, Andrew J — Indiana University Indianapolis
- Study coordinator: Saykin, Andrew J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.