Investigating brain activity patterns in schizophrenia and related mouse models
Spectral Components of Abnormal Spontaneous Gamma Activity in Schizophrenia and Translational Mouse Models
This study is looking at how brain activity works in people with schizophrenia compared to those without, to better understand the brain's balance of signals and how it might affect thinking and behavior.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston VA Research Institute, INC. NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11139127 on NIH RePORTER |
What this research studies
This research explores the spontaneous gamma activity in the brain, which is linked to the balance of excitation and inhibition in the cortex. By using advanced techniques like optogenetic stimulation and receptor blockade, the study aims to understand how these brain activity patterns differ in individuals with schizophrenia compared to healthy individuals. The research also examines the underlying neural mechanisms of these patterns and their potential role in cognitive functions. This could provide insights into the biological basis of schizophrenia and related disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with schizophrenia or related neuropsychiatric disorders.
Not a fit: Patients without a diagnosis of schizophrenia or those with unrelated cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for schizophrenia and related cognitive disorders.
How similar studies have performed: Previous research has shown promising results in understanding gamma activity in neuropsychiatric disorders, indicating that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Boston VA Research Institute, INC. — Boston, United States (Active)
Researchers
- Principal investigator: Spencer, Kevin M — Boston VA Research Institute, INC.
- Study coordinator: Spencer, Kevin M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.