Investigating brain activity patterns in neuropsychiatric disorders
Hippocampal CA2 sharp wave ripple oscillations in neuropsychiatric disease
This study is looking at how certain brain activities affect social behavior in people with schizophrenia, using a special mouse model to find ways to improve social memory, which could help develop new treatments for patients in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10953528 on NIH RePORTER |
What this research studies
This research focuses on understanding the brain mechanisms behind social behavior deficits in individuals with schizophrenia and related neuropsychiatric disorders. By studying a specific mouse model that mimics a genetic risk factor for schizophrenia, the research aims to identify abnormal neural activity patterns in the hippocampus that contribute to these social memory deficits. The approach includes pharmacological and genetic interventions to potentially restore normal brain function and improve social memory. Patients may benefit from insights gained that could lead to new treatment strategies involving brain stimulation.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals diagnosed with schizophrenia or related neuropsychiatric conditions, particularly those experiencing social memory deficits.
Not a fit: Patients without neuropsychiatric disorders or those not exhibiting social memory deficits may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for improving social behaviors in patients with neuropsychiatric disorders.
How similar studies have performed: Previous research has shown promise in using similar approaches to understand and potentially treat neuropsychiatric disorders, indicating that this line of inquiry is both relevant and potentially impactful.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Siegelbaum, Steven a — Columbia University Health Sciences
- Study coordinator: Siegelbaum, Steven a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.