Investigating brain activity in Alzheimer's disease using advanced imaging techniques
Official title: Assessing activation in the human brain using ultra-high performance FDG functional PET to investigate neurodegenerative disorders
Funded at Yale University · NIH-10900927 · Data updated 2026-11-12
This study is looking at a new brain imaging technique to help doctors spot Alzheimer's disease earlier by checking for specific signs in the brain, and it’s designed for people who may be experiencing memory problems.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $33,958 |
| NIH project number | 1F30AG087667-01 |
| Project ID | NIH-10900927 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults who are experiencing cognitive decline or have been diagnosed with Alzheimer's disease or related dementias.
✕Less likely to help
Patients with non-neurodegenerative forms of dementia or those without cognitive impairment may not benefit from this research.
What this research studies
This research focuses on improving the early diagnosis of Alzheimer's disease (AD) and related dementias by utilizing a cutting-edge brain imaging technology called ultra-high performance FDG functional PET. The study aims to assess brain activity and identify specific biomarkers associated with AD, such as amyloid-beta plaques and tau proteins. By enhancing the sensitivity and resolution of brain imaging, the research seeks to provide more accurate measurements of neuronal metabolism, which could lead to better patient stratification for treatment and research studies. Patients may undergo non-invasive imaging to help identify changes in brain function that are indicative of AD.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnoses of Alzheimer's disease, allowing for timely interventions and improved patient outcomes.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques for diagnosing Alzheimer's disease, but this specific approach with ultra-high sensitivity is relatively novel.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Khattar, Nikkita — Yale University
- Study coordinator: Khattar, Nikkita
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.