Investigating brain activity during sleep after learning in Alzheimer's disease models
Cortical-hippocampal brain dynamics during sleep following spatial learning in rodents modeling Tau and AB aggregation feature of Alzheimer's disease
This study is looking at how sleep affects memory in mice that have features of Alzheimer's disease, hoping to learn more about how the brain works during sleep and how it relates to early memory problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Florida State University NIH-funded |
| Lab location | 1 site (Tallahassee, United States) |
| Project ID | NIH-11014054 on NIH RePORTER |
What this research studies
This research focuses on understanding how brain dynamics during sleep are affected by spatial learning in animal models of Alzheimer's disease. Using specially bred mice that mimic key features of the disease, the study will examine the communication between the hippocampus and cortex during sleep, which is believed to be crucial for memory consolidation. By analyzing these interactions, researchers aim to uncover insights into the early memory impairments associated with Alzheimer's. The findings could lead to a better understanding of how sleep influences memory in the context of neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Alzheimer's disease or those experiencing early symptoms of memory impairment.
Not a fit: Patients with advanced Alzheimer's disease or those without cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of memory consolidation processes in Alzheimer's disease, potentially leading to new therapeutic strategies.
How similar studies have performed: Previous studies have shown promising results in understanding brain dynamics in Alzheimer's models, suggesting that this approach could yield valuable insights.
Where this research is happening
Tallahassee, United States
- Florida State University — Tallahassee, United States (Active)
Researchers
- Principal investigator: Wilber, Aaron a — Florida State University
- Study coordinator: Wilber, Aaron a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.