Investigating brain activity changes related to schizophrenia using mouse models
Reverse Translation of Psychosis - associated Hippocampal Hyperactivity in the mouse
This study is looking at how a part of the brain called the hippocampus works in people with schizophrenia, using both human brain samples and mice, to find out what changes happen during episodes of psychosis, which could help create better treatments for those living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10873761 on NIH RePORTER |
What this research studies
This research focuses on understanding how the hippocampus, a brain region important for memory, behaves in individuals with schizophrenia. By examining brain tissue from humans and using mouse models, the researchers aim to identify specific molecular changes that lead to increased activity in the hippocampus during psychosis. They utilize advanced techniques to manipulate brain activity in mice, particularly during adolescence, to better understand the underlying mechanisms of schizophrenia. This approach may help in developing targeted treatments for those affected by this condition.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with schizophrenia, particularly those experiencing early symptoms.
Not a fit: Patients with other mental health conditions unrelated to schizophrenia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing schizophrenia and improving patient outcomes.
How similar studies have performed: Previous studies have shown promising results in understanding schizophrenia through similar approaches, indicating potential for success in this research.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Tamminga, Carol a — Ut Southwestern Medical Center
- Study coordinator: Tamminga, Carol a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.