Investigating brain activity changes related to motor control in mice with dopamine depletion.
Cortical Connectivity and Activity Changes in Motor Preparation and Execution in 6-OHDA-Lesioned Mice
This study is looking at how losing dopamine affects brain activity in mice, which can help us understand movement problems in conditions like Parkinson's disease, and it aims to find new ways to improve treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10930871 on NIH RePORTER |
What this research studies
This research focuses on understanding how dopamine depletion affects brain activity and connectivity in mice, which is relevant to conditions like Parkinson's disease. By using a chemical called 6-OHDA to induce dopamine loss, researchers will study the resulting changes in neuronal activity within specific brain circuits involved in motor control. The approach combines behavioral assessments with detailed analysis of neuron activity to uncover how different types of neurons respond in this parkinsonian state. This could provide insights into the underlying mechanisms of motor dysfunction and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease or those experiencing motor control issues related to dopamine dysfunction.
Not a fit: Patients with motor disorders not related to dopamine depletion or those with other neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with Parkinson's disease and related motor disorders.
How similar studies have performed: Previous research has shown promising results in understanding motor dysfunction through similar approaches in animal models, indicating potential for success in this study.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Jaeger, Dieter — Emory University
- Study coordinator: Jaeger, Dieter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.