Investigating brain activity changes in Alzheimer's disease
Understanding the structural, functional, and prognostic implications of cortical excitability in Alzheimer's disease
['FUNDING_OTHER'] · BETH ISRAEL DEACONESS MEDICAL CENTER · NIH-11166841
This study is looking at how brain activity changes in people with early-stage Alzheimer's disease to help find new ways to treat and understand the condition better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BETH ISRAEL DEACONESS MEDICAL CENTER (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11166841 on ClinicalTrials.gov |
What this research studies
This research explores how brain excitability, measured through a technique called transcranial magnetic stimulation with electroencephalography (TMS-EEG), relates to Alzheimer's disease. By assessing brain activity in specific areas, particularly the motor and parietal cortices, the study aims to understand how these changes correlate with disease progression and brain structure. Participants with early-stage Alzheimer's will undergo tests to evaluate their brain function and connectivity, which may help identify new treatment targets and prognostic markers for the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with early-stage Alzheimer's disease.
Not a fit: Patients with advanced Alzheimer's disease or other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new ways to predict disease progression and develop effective treatments for Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in using TMS-EEG to assess brain function in various neurological conditions, suggesting that this approach may yield valuable insights in Alzheimer's disease as well.
Where this research is happening
BOSTON, UNITED STATES
- BETH ISRAEL DEACONESS MEDICAL CENTER — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BUSS, STEPHANIE — BETH ISRAEL DEACONESS MEDICAL CENTER
- Study coordinator: BUSS, STEPHANIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease and related dementia