Investigating brain activation and its effects on stroke recovery
Official title: Clinical Stimulation and Spreading Depolarization
Funded at University of Virginia · NIH-11158363 · Data updated 2026-11-12
This study is looking at how certain treatments for severe strokes might affect brain activity and whether they could accidentally cause more harm, with the hope of finding better ways to care for stroke patients in the hospital.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $391,638 |
| NIH project number | 7R01NS128006-02 |
| Project ID | NIH-11158363 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with large hemispheric strokes who require decompressive hemicraniectomy and are being treated in intensive care units.
✕Less likely to help
Patients with minor strokes or those not requiring intensive care interventions may not benefit from this research.
What this research studies
This research focuses on understanding how clinical interventions, such as stimulation and physiologic changes, impact patients with severe strokes. It aims to determine if these interventions might inadvertently trigger harmful brain events known as spreading depolarization, which can worsen patient outcomes. By using advanced monitoring techniques, including electrocorticography and tissue oxygen probes, the study will assess brain activity in patients undergoing treatment for large hemispheric strokes. The goal is to improve the management of stroke patients in intensive care settings.
Why it matters
Potential benefit: If successful, this research could lead to safer treatment protocols for stroke patients, minimizing the risk of further brain damage during recovery.
How similar studies have gone: While this approach is based on preliminary data and prior studies, it aims to rigorously assess a novel aspect of stroke management that has not been extensively tested in human subjects.
Where this research is happening
-
University of Virginia
Charlottesville, United States Active
Researchers
- Principal investigator: Carlson, Andrew Phillip — University of Virginia
- Study coordinator: Carlson, Andrew Phillip
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.