Investigating bone metastasis in prostate cancer
Official title: Frontiers in Bone Metastatic Models for Prostate Cancer
Funded at University of Connecticut Sch of Med/dnt · NIH-10946793 · Data updated 2026-11-12
This study is looking at how prostate cancer spreads to the bones, which can be very serious, and aims to find better treatments by using special 3D models to understand the process better, so that patients can have more effective options in the future.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $422,874 |
| NIH project number | 1R21CA282396-01A1 |
| Project ID | NIH-10946793 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with metastatic prostate cancer, particularly those with bone metastases.
✕Less likely to help
Patients with localized prostate cancer or those without bone metastases may not benefit from this research.
What this research studies
This research focuses on understanding how prostate cancer spreads to the bones, which is a major cause of mortality in patients. By developing advanced 3D models that mimic the bone environment, the researchers aim to explore the cellular mechanisms that drive this metastasis. The study will utilize both in vitro and in vivo approaches to test new therapeutic strategies targeting the unique pathways involved in bone metastasis. Patients may benefit from insights gained that could lead to more effective treatments for metastatic prostate cancer.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies that significantly enhance survival rates for patients with metastatic prostate cancer.
How similar studies have gone: Previous research has shown promise in targeting similar pathways in other cancers, indicating potential for success in this novel approach.
Where this research is happening
-
University of Connecticut Sch of Med/dnt
Farmington, United States Active
Researchers
- Principal investigator: Caromile, Leslie Ann — University of Connecticut Sch of Med/dnt
- Study coordinator: Caromile, Leslie Ann
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.