Investigating blood vessel health in people with acute HIV and early treatment
Systemic and Central Nervous System Vasculopathy in Acute HIV and After Early Antiretroviral Therapy
This study is looking at how HIV impacts the health of blood vessels in the brain and body, especially right after someone gets infected and starts treatment, to help find ways to prevent problems like thinking difficulties for people living with HIV.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11084603 on NIH RePORTER |
What this research studies
This research focuses on understanding how HIV affects blood vessel health in the brain and body, particularly during the early stages of infection and after starting treatment. By studying a group of individuals who begin antiretroviral therapy shortly after HIV infection, the researchers aim to identify changes in blood vessel function and how these changes may lead to cognitive issues and other health complications. The study will utilize a well-established cohort in Thailand to gather data on vascular health over time, which could help in developing early interventions for those affected by HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently been diagnosed with HIV and are starting antiretroviral therapy within 30 days of infection.
Not a fit: Patients who are not newly diagnosed with HIV or those who have been on antiretroviral therapy for an extended period may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing cognitive decline and other complications in people living with HIV.
How similar studies have performed: Previous research has shown that understanding vascular health in chronic HIV can lead to better management of related complications, suggesting that this approach may yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Holroyd, Kathryn — Columbia University Health Sciences
- Study coordinator: Holroyd, Kathryn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.