Investigating blood vessel function in CADASIL patients
Official title: Cerebrovascular reactivity as a VCID biomarker in CADASIL
Funded at University of Wisconsin-Madison · NIH-10807518 · Data updated 2026-11-12
This study is looking at how the small blood vessels in the brains of people with CADASIL respond to changes in blood flow, to help spot early signs of thinking and memory problems before they become noticeable, and it includes both CADASIL patients and healthy individuals for comparison.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | September 30, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $801,476 |
| NIH project number | 1R01AG085602-01 |
| Project ID | NIH-10807518 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with CADASIL who carry NOTCH3 mutations.
✕Less likely to help
Patients without CADASIL or those who do not carry NOTCH3 mutations may not benefit from this research.
What this research studies
This research focuses on patients with CADASIL, a genetic condition that affects blood vessels and can lead to strokes and cognitive decline. The study will examine how well the small blood vessels in the brain respond to changes in blood flow, particularly in individuals with specific genetic mutations. By analyzing cerebrovascular reactivity, researchers aim to identify early signs of vascular contributions to cognitive impairment and dementia before clinical symptoms appear. The project involves a cohort of CADASIL patients and non-carrier controls to compare vascular health.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better management of cognitive decline in CADASIL patients.
How similar studies have gone: Previous research has shown promise in using cerebrovascular reactivity as a marker for vascular health in similar conditions, indicating potential for success in this approach.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Barnes, Jill Nicole — University of Wisconsin-Madison
- Study coordinator: Barnes, Jill Nicole
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.