Investigating blood vessel changes in Parkinson's disease and ALS
Single Cell Dissection of Cerebrovascular Dysfunction in Parkinson's Disease and Amyotrophic Lateral Sclerosis
This study is looking at how problems with blood vessels in the brain might make Parkinson's disease and ALS worse, and it hopes to find new ways to help treat these conditions by understanding the early changes that happen in the brain.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts Institute of Technology NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10893022 on NIH RePORTER |
What this research studies
This research focuses on understanding how cerebrovascular dysfunction contributes to the progression of Parkinson's disease and Amyotrophic Lateral Sclerosis (ALS). By examining the specialized cells that make up the cerebrovascular system, the study aims to uncover the molecular changes that occur early in these diseases. The approach includes analyzing blood-brain barrier integrity, blood flow regulation, and immune cell activity, which may provide insights into potential therapeutic targets. Patients may benefit from findings that could lead to new treatments aimed at modifying disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease or Amyotrophic Lateral Sclerosis.
Not a fit: Patients with other neurodegenerative diseases or those without a diagnosis of Parkinson's disease or ALS may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for slowing or altering the course of Parkinson's disease and ALS.
How similar studies have performed: Previous research has shown promising results in understanding cerebrovascular changes in neurodegenerative diseases, indicating that this approach could yield valuable insights.
Where this research is happening
Cambridge, United States
- Massachusetts Institute of Technology — Cambridge, United States (Active)
Researchers
- Principal investigator: Linville, Raleigh Miller — Massachusetts Institute of Technology
- Study coordinator: Linville, Raleigh Miller
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.