Investigating blood vessel and lymphatic issues in Parkinson's disease using advanced MRI techniques
Advanced MRI studies of cerebrovascular and lymphatic abnormalities in LRRK2 mouse models of Parkinson's disease
This study is looking at how problems with blood vessels and lymphatic systems might play a role in Parkinson's disease, using special MRI scans on mice to find changes that could help us diagnose and track the disease earlier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11064849 on NIH RePORTER |
What this research studies
This research focuses on understanding how abnormalities in blood vessels and lymphatic systems contribute to Parkinson's disease. By using advanced MRI techniques, the study aims to identify specific changes in these systems in mouse models of the disease. The goal is to develop biomarkers that can help in the early diagnosis and monitoring of Parkinson's disease progression. This research could lead to better insights into the disease mechanisms and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease or those at risk of developing it.
Not a fit: Patients with other neurodegenerative diseases unrelated to Parkinson's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatment strategies for patients with Parkinson's disease.
How similar studies have performed: Other research has shown promise in using advanced imaging techniques to study neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Smith, Wanli W — Johns Hopkins University
- Study coordinator: Smith, Wanli W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.