Investigating blood protein markers related to Alzheimer's disease progression
Serum protein markers along the Alzheimer's disease trajectory in the population-based longitudinal AGES Reykjavik study and their offsprings
This study is looking for specific proteins in the blood that could help spot early signs of Late Onset Alzheimer's Disease before any symptoms show, using data from over 5,000 people to see how these proteins connect to brain changes and memory issues, while also checking how genetics might play a role in the disease's progression.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icelandic Heart Association NIH-funded |
| Lab location | 1 site (Kopavogur, Iceland) |
| Project ID | NIH-11053000 on NIH RePORTER |
What this research studies
This research focuses on identifying blood protein markers that can help detect early stages of Late Onset Alzheimer's Disease (LOAD) before symptoms appear. By analyzing a large dataset from the AGES Reykjavik study, which includes information from over 5,000 participants, the study aims to uncover how these markers relate to brain changes and cognitive decline. The research will also explore genetic factors, particularly the APOE-ε4 gene, to understand how they influence the progression of Alzheimer's. This approach could lead to more personalized treatment strategies for those at risk of developing the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those showing early signs of cognitive decline.
Not a fit: Patients who are already diagnosed with advanced Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and more effective interventions for Alzheimer's disease, improving patient outcomes.
How similar studies have performed: Previous research has shown promise in using blood biomarkers for early detection of Alzheimer's, suggesting that this approach could be effective.
Where this research is happening
Kopavogur, Iceland
- Icelandic Heart Association — Kopavogur, Iceland (Active)
Researchers
- Principal investigator: Gudmundsdottir, Valborg — Icelandic Heart Association
- Study coordinator: Gudmundsdottir, Valborg
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.