Investigating blood markers related to blood vessel changes in Alzheimer's disease
Official title: Molecular Markers of Cerebrovascular Pathologies in Alzheimer's Disease and Related Dementias
Funded at University of California Riverside · NIH-11081921 · Data updated 2026-11-12
This study is looking at how problems with blood vessels might be connected to Alzheimer's disease and aims to find certain proteins in the blood that could help us understand how the disease develops, especially by considering differences between men and women.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Riverside NIH-funded |
| Lab location | 1 site (Riverside, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $614,893 |
| NIH project number | 7R01NS135556-02 |
| Project ID | NIH-11081921 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for Alzheimer's disease, particularly those with a family history or early signs of cognitive decline.
✕Less likely to help
Patients with advanced Alzheimer's disease or those without any risk factors for the disease may not benefit from this research.
What this research studies
This research focuses on understanding how changes in blood vessels are linked to Alzheimer's disease and related dementias. It aims to identify specific blood-borne protein biomarkers that indicate vascular dysfunction and how these relate to the progression of the disease. By studying both animal models and human subjects, the research will explore the connections between vascular health and Alzheimer's, particularly looking at differences based on sex. The goal is to fill a critical gap in knowledge that could lead to better predictions of disease onset and progression.
Why it matters
Potential benefit: If successful, this research could lead to new methods for predicting Alzheimer's disease vulnerability and progression, potentially improving early diagnosis and treatment strategies.
How similar studies have gone: While there has been significant research on Alzheimer's disease, this specific approach linking vascular changes to blood biomarkers is relatively novel and has not been extensively tested.
Where this research is happening
-
University of California Riverside
Riverside, United States Active
Researchers
- Principal investigator: Obenaus, Andre — University of California Riverside
- Study coordinator: Obenaus, Andre
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.