Investigating blood markers in childhood anaplastic large cell lymphoma
Official title: Circulating biomarkers of ALK+ anaplastic large cell lymphoma
Funded at Sloan-Kettering Inst Can Research · NIH-10896343 · Data updated 2026-11-12
This study is looking at blood samples from kids with anaplastic large cell lymphoma (ALCL) to find specific markers that can help doctors understand how the cancer behaves and how well treatments are working, making it easier to keep track of their health without needing invasive tests.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | October 1, 2022 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $288,649 |
| NIH project number | 5R01CA255350-05 |
| Project ID | NIH-10896343 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years diagnosed with anaplastic large cell lymphoma.
✕Less likely to help
Patients with other types of cancers or those outside the specified age range may not benefit from this research.
What this research studies
This research focuses on understanding the role of circulating biomarkers in children with anaplastic large cell lymphoma (ALCL), a type of cancer that affects the lymphatic system. The study aims to identify specific genetic alterations and proteins associated with ALCL, particularly those linked to the ALK gene. By using advanced techniques like digital droplet PCR, researchers will analyze blood samples to detect these biomarkers, which could help predict disease progression and response to treatment. This non-invasive approach may provide valuable insights into the disease and improve monitoring for patients undergoing therapy.
Why it matters
Potential benefit: If successful, this research could lead to better monitoring and treatment strategies for children with ALCL, potentially improving their outcomes.
How similar studies have gone: Previous research has shown promise in using circulating biomarkers for monitoring various cancers, suggesting potential success for this approach in ALCL.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Lim, Megan S. — Sloan-Kettering Inst Can Research
- Study coordinator: Lim, Megan S.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.