Investigating blood flow issues in Alzheimer's disease and related conditions
Official title: Pathophysiological mechanisms of hypoperfusion in mouse models of Alzheimer?s disease and small vessel disease
Funded at Johns Hopkins University · NIH-11015806 · Data updated 2026-11-12
This study is looking at how lower blood flow affects thinking and memory in people with Alzheimer's and small vessel disease, using mice to help find out more about what causes these issues and how we might improve treatment for dementia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | May 15, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $514,625 |
| NIH project number | 5R01AG081932-03 |
| Project ID | NIH-11015806 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with Alzheimer's disease or related dementias, particularly those experiencing cognitive deficits.
✕Less likely to help
Patients with non-dementia related cognitive impairments or those without Alzheimer's disease may not benefit from this research.
What this research studies
This research focuses on understanding how reduced blood flow, known as hypoperfusion, affects cognitive function in Alzheimer's disease and small vessel disease. By using mouse models, the study aims to explore various vascular and metabolic factors that contribute to this condition. Researchers will conduct a detailed analysis to identify the relationship between blood flow and cognitive deficits, which may lead to better understanding and potential treatments for dementia. The approach includes examining multiple parameters beyond just blood flow to gain a comprehensive view of the underlying mechanisms.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatment strategies for patients with Alzheimer's disease and related dementias.
How similar studies have gone: Previous research has shown promising results in understanding vascular contributions to cognitive impairment, indicating that this approach may yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Wei, Zhiliang — Johns Hopkins University
- Study coordinator: Wei, Zhiliang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.