Investigating blood flow in the brain related to Alzheimer's disease
High-speed imaging of cortical and white matter microvascular flow in AD/ADRD models
This study is looking at how blood flow in the brain changes in people with Alzheimer's and similar conditions, using special imaging to see tiny blood vessels, so we can better understand what causes brain problems and find new ways to help.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-10523289 on NIH RePORTER |
What this research studies
This research focuses on understanding how blood flow in the brain is affected in models of Alzheimer's disease and related disorders. By using high-speed imaging techniques, the study aims to observe microvascular flow in both cortical and white matter regions of the brain. The researchers will analyze how various factors, such as genetic mutations and cardiovascular risks, contribute to decreased blood flow and dysfunction in the brain's microvascular network. This could help identify specific mechanisms that lead to neurodegeneration and inform future treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with Alzheimer's disease or related disorders, particularly those with known vascular risk factors.
Not a fit: Patients without Alzheimer's disease or related neurodegenerative conditions are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the vascular contributions to Alzheimer's disease, potentially guiding more effective treatments.
How similar studies have performed: Previous research has shown promising results in understanding vascular dysfunction in Alzheimer's models, suggesting that this approach could yield valuable insights.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Schaffer, Chris B — Cornell University
- Study coordinator: Schaffer, Chris B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.