NIH-funded research R01 grant

Investigating blood flow changes in glaucoma

Official title: Blood flow and hemodynamics in glaucoma

Funded at Legacy Emanuel Hospital and Health Center · NIH-10701693 · Data updated 2026-11-12

This study is looking at how blood flow changes in the eyes of people with glaucoma, which could help us find better ways to catch the disease early and protect your vision.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionLegacy Emanuel Hospital and Health Center
NIH-funded
Lab location1 site (Portland, UNITED STATES)
Project startSeptember 30, 2020
Project endAugust 31, 2025
Funding year2023
Award (this year)$526,740
NIH project number5R01EY031686-04
Project IDNIH-10701693 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research include individuals diagnosed with glaucoma or those identified as glaucoma suspects.

Less likely to help

Patients with other unrelated eye conditions or those without any signs of glaucoma may not benefit from this research.

What this research studies

This research focuses on understanding how blood flow and hemodynamics are altered in patients with glaucoma, a leading cause of blindness. The study will utilize advanced technologies to measure blood flow in the optic nerve head and retina at various stages of the disease. By examining these changes, researchers aim to determine whether they contribute to retinal ganglion cell damage or are a result of it. This could lead to better diagnostic methods for identifying glaucoma in its early stages.

Why it matters

Potential benefit: If successful, this research could lead to improved diagnostic techniques and treatments for glaucoma, potentially preserving vision in affected patients.

How similar studies have gone: Previous research has shown promising results in understanding blood flow dynamics in glaucoma, suggesting that this approach could yield valuable insights.

Where this research is happening

  • Legacy Emanuel Hospital and Health Center
    Portland, United States
    Active

Researchers

  • Principal investigator: Gardiner, Stuart — Legacy Emanuel Hospital and Health Center
  • Study coordinator: Gardiner, Stuart

Related research

Other NIH-funded projects on the same topics.

  • IOP and CSF Pressure in Glaucoma Risk

    This grant studies how eye pressure and cerebrospinal fluid pressure together influence glaucoma risk and vision loss.

    NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11644421

  • New retinal imaging to detect brain small vessel disease

    A fast, wide-field eye imaging method will measure how tiny retinal blood vessels rhythmically flow to help detect early brain small vessel disease.

    NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11607100

  • Comparing tube positions in glaucoma implants to protect corneal cells

    This trial compares two tube placements for glaucoma drainage implants to see which better protects corneal cells and controls eye pressure in people with uncontrolled glaucoma.

    NIH research University of California, San Francisco · San Francisco, United States · NIH-11520347

  • Automated topographic test for glaucoma detection and progression

    A new automated method uses topographic structure-function mapping to help diagnose glaucoma earlier and track its progression in patients.

    NIH research Columbia University Health Sciences · New York, United States · NIH-11516608

  • Platelet markers and blood flow to predict recurrent stroke in intracranial artery disease

    Researchers will look at how a platelet protein (FcγRIIa) and blood flow patterns from CT angiography predict who might have another stroke after a minor stroke or TIA caused by intracranial artery disease.

    NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11504575

  • Using AI on eye scans and genes to predict glaucoma risk

    This project uses artificial intelligence on eye scans, vision tests, and genetic information to find people most likely to develop or have worsening glaucoma.

    NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11469603

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.