Investigating blood flow and brain function in Alzheimer's disease
Official title: Hypoperfusion, Hemodynamic Control Domains and Neurovascular Dysregulation in AD brain pathology
Funded at Duke University · NIH-11021073 · Data updated 2026-11-12
This study is looking at how blood flow and brain function change in mice with Alzheimer's disease compared to healthy mice, to help find new ways to support brain health for people living with Alzheimer's.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project start | May 15, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $452,171 |
| NIH project number | 5R01AG081774-03 |
| Project ID | NIH-11021073 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it, particularly older adults.
✕Less likely to help
Patients with early-stage cognitive impairment not related to Alzheimer's disease may not benefit from this research.
What this research studies
This research focuses on understanding how blood flow and neurovascular regulation are affected in the brains of individuals with Alzheimer's disease (AD). By studying a specific mouse model that mimics human AD, researchers aim to identify the mechanisms that lead to reduced blood supply and metabolic changes in the aging brain. The study will compare these mechanisms in age-matched control mice and those with AD to uncover potential differences that contribute to disease progression. The findings could help in developing new strategies for improving brain health in patients with AD.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential treatments that improve blood flow and brain function in patients with Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in understanding neurovascular regulation in Alzheimer's disease, suggesting that this approach could lead to significant advancements.
Where this research is happening
-
Duke University
Durham, United States Active
Researchers
- Principal investigator: Turner, Dennis Alan — Duke University
- Study coordinator: Turner, Dennis Alan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.