Investigating blood disorders like von Willebrand Disease and sickle cell disease
Official title: Molecular and Translational Studies in Hematologic Disorders
Funded at Bloodworks · NIH-11039754 · Data updated 2026-11-12
This study is looking at how problems with a blood protein called von Willebrand factor affect people with von Willebrand Disease and how changes in fat in sickle cells impact those with sickle cell disease, with the hope of finding better treatments for both conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Bloodworks NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | March 1, 2025 |
| Project end | February 28, 2032 |
| Funding year | 2025 |
| Award (this year) | $1,276,908 |
| NIH project number | 1R35HL177719-01 |
| Project ID | NIH-11039754 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with von Willebrand Disease or sickle cell disease.
✕Less likely to help
Patients with other hematologic disorders not related to VWD or SCD may not receive direct benefits from this research.
What this research studies
This research focuses on understanding the mechanisms behind von Willebrand Disease (VWD) and sickle cell disease (SCD), both of which involve the von Willebrand factor (VWF). The study will explore how dysfunctional VWF affects blood clotting in VWD and how changes in lipid composition in sickle cells contribute to complications in SCD. By examining the roles of various blood components and their interactions, the research aims to uncover new insights that could lead to improved treatments. Patients may benefit from advancements in understanding their conditions and potential new therapeutic approaches.
Why it matters
Potential benefit: If successful, this research could lead to better management and treatment options for patients with von Willebrand Disease and sickle cell disease.
How similar studies have gone: Previous research has shown promise in understanding the roles of VWF and lipid changes in blood disorders, indicating that this approach could yield valuable insights.
Where this research is happening
-
Bloodworks
Seattle, United States Active
Researchers
- Principal investigator: Lopez, Jose Aron — Bloodworks
- Study coordinator: Lopez, Jose Aron
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.