Investigating blood clotting risks in critically ill children on ventilators
Official title: Functional Fibrinolysis, Thromboinflammation and VTE Risk for Ventilated Children
Funded at Johns Hopkins University · NIH-11032327 · Data updated 2026-11-12
This study is looking at critically ill children on breathing machines to find out who is most likely to develop dangerous blood clots, so doctors can better prevent these clots while keeping an eye on bleeding risks, ultimately making sure these kids stay as safe as possible.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $198,720 |
| NIH project number | 1K23HL177270-01 |
| Project ID | NIH-11032327 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are critically ill children aged 0-21 who are undergoing invasive mechanical ventilation.
✕Less likely to help
Patients who are not critically ill or who are not on mechanical ventilation may not benefit from this research.
What this research studies
This research focuses on critically ill children who are on invasive mechanical ventilation and are at high risk for developing blood clots, known as hospital-acquired venous thromboembolism (HA-VTE). The study aims to create predictive models to identify which children are most at risk for these complications while also considering their risk of bleeding. By analyzing the intensity of mechanical ventilation and specific blood markers, the researchers hope to develop tailored thromboprophylaxis strategies that can improve patient safety and outcomes. This approach seeks to balance the risks of clotting and bleeding in this vulnerable population.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective prevention strategies for blood clots in critically ill children.
How similar studies have gone: Previous research has shown promise in developing risk stratification models for thromboembolism in pediatric populations, but this specific approach is novel.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Sochet, Anthony a — Johns Hopkins University
- Study coordinator: Sochet, Anthony a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.